English for Pharmacists > Intermediate Level > Vocabulary > Pharmacokinetics

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Spanish English Definition
Absorción

Absorption
X

Process by which a drug moves from its site of administration, usually across biological membranes, to the systemic circulation or its site of action in the body.
X

Aclaramiento

Clearance
X

The complete and irreversible elimination of a drug from the body; expressed as the volume of plasma from which drug is completely removed per unit of time.
X

Administración

Administration
X

Application of a known amount of a substance to an organism, in a reproducible manner and by a defined route.
X

Biodisponibilidad

Bioavailability
X

A measurement of the rate and extent to which a drug reaches the systemic circulation.
X

Compartimento

Compartment
X

Conceptualized part of the body (organs, tissues, cells, or fluids) considered as an independent system, for purposes of modelling and assessment of distribution and clearance of a substance.
X

Concentración

Concentration
X

Amount of drug in a given volume of plasma.
X

Disgregación

Disintegration
X

The physical break-up of an intact dosage form to its component aggregates.
X

Disposición

Disposition
X

The fate of a therapeutic agent after absorption, which corresponds to the sum of its distribution and elimination.
X

Distribución

Distribution
X

Reversible transfer of drug between the systemic circulation and various sites within the body.
X

Dosis

Dose
X

A specified quantity of a therapeutic agent, such as a drug, prescribed to be taken at one time or at stated intervals.
X

Dosis de choque

Loading dose
X

A comparatively large dose given at the beginning of treatment to start getting the effect of a drug.
X

Dosis de mantenimiento

Maintenance dose
X

Dose which should achieve an almost constant effect without marked fluctuations in plasma concentrations.
X

Eliminación

Elimination
X

Removal of drugs from the body.
X

Excreción

Excretion
X

Combination of mechanisms by which a drug is irreversibly transferred from the systemic circulation into extracorporeal fluids.
X

Intervalo posológico

Dosing interval
X

Time between drug dose administrations.
X

Liberación

Liberation
X

The process of release of a drug from the pharmaceutical formulation.
X

Metabolismo

Metabolism
X

Drug biotransformation, generally into more polar compounds readily excreted from the body through urine or faeces.
X

Rango terapéutico

Therapeutic range
X

The range of concentrations at which a drug or other therapeutic agent is effective, with minimal toxicity to most patients.
X

Régimen posológico

Dosage regimen
X

Decision of drug administration regarding formulation, route of administration, drug dose, dosing interval and treatment duration, chosen to reach the therapeutic objective.
X

Semivida

Half-life
X

Time it takes for the plasma concentration or the amount of drug in the body to be reduced by 50%.
X

Vía de administración

Route of administration
X

The path by which a drug is taken into the body.
X

Volumen de distribución

Volume of distribution
X

Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma.
X

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